下記論文のPage 3 > most ES cell clones with a normal karyotype gave rise to a > high percentage of chimeras and contributed to the germ line > whereas none of the ES cell clones with trisomy 8 produced chimeras > that transmitted the mutation to the germ line. onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0177(199705)209:1%3C85::AID-AJA8%3E3.0.CO;2-T/abstract;jsessionid=E3AD25437CBC6BBF90BE925219BE2EA4.f03t03