耳鼻咽喉科について　Vol.29

耳鼻咽喉科について　 ..

99:79
09/07/10 00:23:42 +B9smBNh0
>>98　つづき

RESULTS:
Cluster patterns of concentrations of　cytokines were examined by unsupervised
hierarchical clustering algorithms. Four major cluster groups were identified,
one of the groups was significantly
enriched for cases of respiratory syncytial virus (RSV)-induced AOM as compared
with other viruses. Specifically, RSV-induced AOM had significantly higher
concentrations of G-CSF, MCP-1, IL-10, IL-6, interferon-gamma, and IL-8 (P < 0.05).
Using a decision tree classifier, higher G-CSF concentrations produced 87.6% accuracy
to predict RSV-induced AOM. Overall, higher IL-13 concentrations produced 84.2%
accuracy to predict early clinical failure of antibiotic treatment.
CONCLUSIONS:
Children with AOM have a unique pattern of systemic cytokine response that relates
to virus etiology and clinical outcome. Based on G-CSF and IL-13 measurements,
it is possible to accurately classify RSV-induced AOM and early treatment failure,
respectively; these observations will need to be validated in an independent population.

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