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821:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:02:23.09 T/5MauaB0.net
¦Trial Profile: A randomized, double-blind, placebo controlled, dose ranging study to assess the safety, tolerability, and efficacy of HTL0018318 in patients with dementia with Lewy bodies: JapicCTI-183989(6/6V‹Kì¬)F—\’莎Œ±ŠúŠÔF2018/6/1`2020/7/31A”팱ŽÒ•åWó‹µF•åW‘OA“ú–{. (6/28update)
¦ˆã–ò•iŒ´—¿‘Û“Win-Pharma Japan (JITSUBOo“W6/27~6/29)E‹ZpƒZƒ~ƒi[‚àŠJÃuV‹Kƒyƒvƒ`ƒhŒ´–ò»‘¢–@‚ÌŠJ”­vF‰t‘ŠAŒÅ‘Š‡¬–@‚É‘±‚­‘æ3¢‘ã‚̃yƒvƒ`ƒh‡¬‹ZpMolecular Hiving‚Ì‘n–òŒ¤‹†‚¨‚æ‚ÑŒ´–ò»‘¢‚Ö‚Ì“K—p‚ÆAX‚È‚éi‰»‚Ö‚ÌŽæ‚è‘g‚ÝЉîB(6/29)
¦ClinicalTrials(NCT03381274): Phase 1b/2, Oleclumab(MEDI9447) EGFRm NSCLC Novel Combination Study. (MEDI9447 with Osimertinib or AZD4635, AZD4635 with MEDI9447). Research Site Status Change: Korea Seoul: "Recruiting". (6/29update)
¦Nathan Robertson: The 11 years at Heptares have been the most exciting, scientifically enriching and rewarding years I have had. Thank you to all the wonderful and highly talented scientists at Heptares, you will be missed. (6/29)
¦‘åã‘åŠw‘åŠw‰@ˆãŠwŒnŒ¤‹†‰ÈFu”F’mǃvƒŒƒVƒWƒ‡ƒ“ˆã—ÊJ”­ŠwvŠñ•uÀŠJu(Šñ•uÀ‹³ŽöFXŒ´„Žj)B”­ÇƒƒJƒjƒYƒ€‚Ì•ªŽqƒŒƒxƒ‹‚̉𖾂ƃoƒCƒIƒ}[ƒJ[‚ÌŠJ”­A”F’mǃTƒuƒOƒ‹[ƒv‚ɑ΂·‚éŒø—¦“I‚ÈŽ¡—Ö@ŠJ”­‚ð–ÚŽw‚·B—Õ°‚Æ•ªŽq¶•¨Šw‚Ì—¼•ª–ì‚É‹­‚¢ã‘å¸_‰È‚Ì‹­‚Ý‚ðŠˆ‚©‚·B(7/1)
¦‚»[‚¹‚¢CVCFSosei RMF1 (Ķˆã—Ãtƒ@ƒ“ƒh)“ŠŽ‘æ‚ÌŠ”Ž®‰ïŽÐƒWƒFƒmƒ~ƒbƒNƒX‚ªAŠ”Ž®‰ïŽÐƒXƒeƒ€ƒŠƒ€‚ɎЖ¼‚ð•ÏXB(7/1)
¦Department of Biochemistry at the University of Oxford: "2018 Sosei Heptares Prize for Biophysics to be awarded to Prof Elspeth Garman". Contributed to the improvement of X-ray crystallography and structural biology. (7/2)
¦“ú–{‘“Á‹–’¡(ŒöŠJ¤•WŒö•ñ)Fy¤•WzMATILDA yyoŠèlzƒwƒvƒ^ƒŒƒXyoŠè”Ô†z¤Šè2018-79942yoŠè“úz2018/6/18yŒöŠJ“úz2018/7/3B(7/3ŒöŠJ)
¦World Congress of Basic and Clinical Pharmacology, Kyoto: "PLX-R18- Placenta-derived Mesenchymal-like Stromal Cells are efficacious in reducing lethality in Gastrointestinal Acute Radiation Syndrome (GI-ARS) Mouse Model": Yoshiyuki Soeda, Fukushima Medical University. (7/3 Presented)
¦‘åã‘åŠw‘åŠw‰@ˆãŠwŒnŒ¤‹†‰È ¸_ˆãŠw‹³Žº ƒXƒ^ƒbƒtXVBŠñ•uÀ‹³ŽöFXŒ´„Žji”F’mÇÌßÚ¼¼Þ®Ýˆã—ÊJ”­ŠwjŠñ•uÀuŽtF‰i“cŒ’ˆêi”F’mÇÌßÚ¼¼Þ®Ýˆã—ÊJ”­Šwj(7/5update)
¦MiNA Therapeutics_HP: Renewal. "Development Programs" update. (7/3up)@¦MiNA Therapeutics: Exited to launch our new website. Head minatx.com to learn more about small activating RNA medicines. (7/6)
¦World Congress of Basic and Clinical Pharmacology (WCP2018) Kyoto: "Biased apelin receptor agonists for cardiovascular disease" :Anthony P. Davenport, University of Cambridge, UK, (Heptares ORBIT Projects). (7/6 Presented)
¦Heptares: "Receptionists - Jobshare (25 hours per week)": We are now seeking to recruit two highly motivated part-time receptionists to join the Operations team. (7/6 Closed)
¦Pluristem: Signs Collaboration Agreement With Thermo Fisher Scientific: Advance fundamental knowledge of cell therapy industrialization and to improve quality control of the end-to-end supply chain. "A potential to advance the industry significantly". (7/9)
¦Nature: "PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling" Acknowledgements: Christopher G. Tate acknowledges the MRC, an ERC Advanced Grant EMPSI and funding from Heptares Therapeutics. (7/11)
¦Daniel J. Scott(Fiona Marshall, Nathan Robertson, Retweet): Cool use of a StaR, a CHESS-stabilized GPCR and MS to investigate GPCR-lipid interactions. (7/12)
¦British Biophysical Society (BBS) Biennial Meeting: Sosei Heptares Prize for Biophysics: "X-rays in, X-rays out, structure-function not in doubt ": Elspeth Garman, University of Oxford. (7/12Awards Lecture)

822:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:02:47.39 T/5MauaB0.net
¦ClinicalTrials(NCT02740985): A Phase 1 (Ph1b Expansion Cohorts) Clinical Study of AZD4635 and Durvalumab in Patients With Advanced Solid Malignancies. Enrollment: 156¨"206h(Change), Secondary Outcome Measures (Change), Eligibility (Change), Study Research Site (Add). (7/16update)
¦ClinicalTrials(NCT02571777): Phase 3, Study to Compare the Efficacy and Safety of QVM149 With QMF149 in Patients with Asthma. Study Locations: (Research Site update, Research Site Status update). (7/16update)
¦ŒÂ•ÊŠ”î•ñFƒhƒCƒcØŒ”‚ł̓|ƒWƒeƒBƒu‚ȃJƒ^ƒŠƒXƒg‚ª‚È‚¢‚½‚ßAŽã‹CƒZƒ“ƒ`ƒƒ“ƒg‚ª‘±‚­Œ©’Ê‚µBŒ»sŠ”‰¿‚̓pƒCƒvƒ‰ƒCƒ“‚𒘂µ‚­‰ß¬•]‰¿‚µ‚Ä‚¨‚èA18”N‰ºŠú‚É“ü‚ê‚΃|ƒWƒeƒBƒu‚ȃJƒ^ƒŠƒXƒg‚É‚æ‚Á‚ăZƒ“ƒ`ƒƒ“ƒg‚ªD“]‚·‚é‰Â”\«B(7/18)
¦Novartis Q2 2018 Results: Continued Strong Growth of Ultibro (USD 116 million, +11% cc). QVM149 Asthma: First planned submissions: "2019", Expected Launches: "2020". News update: "QVM149 IRIDIUM study enrollment completed end of April". (7/18)
¦SOSEIF¢ƒV[ƒuƒŠ‚¨‚æ‚уEƒ‹ƒeƒBƒuƒ£‚Ì2018”N‘æ2Žl”¼Šú(4ŒŽ〜6ŒŽ)‚Ì‹ÆÑBƒEƒ‹ƒeƒBƒuƒ‚Í“–Žl”¼Šú‚É‚¨‚¢‚ÄAFLAME, CLAIM study‚Ì—ÇD‚ÈŒ‹‰ÊA2018”N”ÅGOLDƒŒƒ|[ƒgA‚³‚ç‚ÉSUNSET study‚Ɍ㉟‚µ‚³‚êA”„ã‚Í“ñŒ…‚ÌL‚ÑBƒV[ƒuƒŠ‚Ì”„ã‚ÍA‚Ù‚Ú‰¡‚΂¢B(7/18)
¦•Ä‘“Á‹–oŠè(MiNA)FAlbumin Production and Cell Proliferation. (7/19ŒöŠJ)
¦JapicCTI-183989FƒŒƒr[¬‘ÌŒ^”F’mÇŠ³ŽÒ‚ð‘ÎÛ‚Æ‚µ‚½HTL0018318‚̈À‘S«A”E—e«‹y‚Ñ—LŒø«‚ð•]‰¿‚·‚é–³ìˆ×‰»“ñd–ÓŒŸƒvƒ‰ƒZƒ{‘ÎÆ—p—ʔ͈͒TõŽŽŒ± (—\’莎Œ±ŠúŠÔF2018/6/1`2020/7/31A–Ú•WÇ—á”172A”팱ŽÒ•åWó‹µF•åW‘O¨ŽQ‰ÁŽÒ•åW’†A“ú–{)B(7/19‰ü’ù)
¦ClinicalTrials(NCT03592862: HTL0018318-203): Phase 2, A Study to Assess Safety, Tolerability, and Efficacy of HTL0018318 in Patients With Dementia With Lewy Bodies (DLB). Study Start: "August 2018". Primary Completion: "July 2020", Study Completion: "January 2021". (7/19up, "New Trial Record".)
¦ClinicalTrials(NCT03456349: HTL0018318-202): Phase 1b, Multi-center Study to Determine the Safety and


823:Tolerability of HTL0018318 in Subjects With Alzheimer's Disease Receiving Standard-of-care. Actual Study Completion: "2018/7/16" (7/20update, "Completed".) ¦‚»[‚¹‚¢CVCFSosei RMF1 (Ķˆã—Ãtƒ@ƒ“ƒh)‚©‚犔Ž®‰ïŽÐchromocenter‚Ö‚Ì“ŠŽ‘‚ðŽÀsB(7/20) ¦Pluristem: Company Presentation July 2018: PLX-PAD CLI: Single pivotal study (Japan PMDA). Collaboration with Fukushima Medical University: Collaboration with Fukushima Medical University: Suggesting PLX-R18 potential as a multi-organ therapy for radiation exposure. (7/23update) ¦ƒgƒŒ[ƒ_[ƒYEƒEƒFƒuF’˜–¼“ŠŽ‘‰Æ‚ªŠ””ƒ‚¢‘‚µB23“úŒö•\‚Ì‘å—Ê•Û—L•ñ‘‚ÅA“¯ŽÐ‚Ì•M“ªŠ”Žå‚Å‚à‚ ‚éŒÜ–¡‘å•ãŽ‚ª19“úŽž“_‚Å•Û—LŠ””ä—¦‚ð]—ˆ‚Ì6.13“‚©‚ç7.16“‚ւƈø‚«ã‚°‚½‚±‚Æ‚ª”»–¾‚µA“ŠŽ‘–­–¡‚ª‚ ‚é‚Æ‚ÌŠú‘Ò‚©‚甃‚¢‚ªW’†B(7/24) ¦•Ä‘“Á‹–(Heptares)FPiperidin-1-yl and Azepin-1-yl Carboxylates as Muscarinic M4 Receptor Agonists. (7/24ŒöŠJ) ¦•Ä‘“Á‹–(Heptares)FMuscarinic receptor agonists. (7/24ŒöŠJ) ¦JITSUBOFu“ú–{ƒvƒƒZƒX‰»Šw‰ï2018ƒTƒ}[ƒVƒ“ƒ|ƒWƒEƒ€‚É‚Ä(ƒ|ƒXƒ^[”­•\2“ú–Ú(7/2714:40`16:20)F2P-37u‘a…«ƒ^ƒO‚ð—p‚¢‚½Icatibant Acetate‚̇¬v‹v•Û‘å•ã (JITSUBO) )”­•\‚µ‚Ü‚·Bv(7/25) ¦ClinicalTrials(NCT03100825): Phase 3, A Long-term Safety Study of QVM149 in Japanese Patients With Asthma. Study Start: "2017/4/13 [Actual]", Primary Completion: 2018/9/18, Study Completion: "2019/4/8, Study Enrollment: "94 participants [Actual]". (7/24update) ¦ƒƒ‹ƒgƒŒF‚»[‚¹‚¢ƒOƒ‹[ƒvHTL18318‚Ì‘“àƒtƒF[ƒY2ŽŽŒ±‚ª8ŒŽ‚ÉŠJŽnBuHTL18318 ƒZ[ƒ‹ƒXƒs[ƒN800‰­‰~—\‘zvB‘“à‘åŽèØŒ”ƒoƒCƒIƒZƒNƒ^[ƒAƒiƒŠƒXƒg‚ÍAud—v‚Èi’»‚Ńvƒ‰ƒX‚ȈóÛv‚ƃRƒƒ“ƒgB¡‰ñ‚ÌŽŽŒ±ŠúŠÔ‚Í2018”N8ŒŽ`2021”N1ŒŽ‚Ì—\’èAŠ³ŽÒ”172lA—LŒø«‚ÌŠÏŽ@ŠúŠÔ‚Í12TŠÔB(7/25)



824:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:03:16.49 T/5MauaB0.net
¦‚¢‚¸‚Ý‚Ì•a‰@(‘n–òƒZƒ“ƒ^[‚¢‚¸‚Ý‚Ì)‘æ103‰ñŽ¡Œ±R¸ˆÏˆõ‰ïFyR¸Ž–€zŽ¡Œ±(‚»[‚¹‚¢ˆË—Š‚É‚æ‚郌ƒr[¬‘ÌŒ^”F’mÇŠ³ŽÒ‘ÎÛ HTL0018318ŽŽŒ±)‚ÌŽÀŽ{‚Ì“K”ۂɂ‚¢‚ÄFyR¸Œ‹‰ÊzF—¹³B(7/25)
¦Heptares: "All set for our study of HTL0018318 in Patients with Dementia with Lewy Bodies (DLB)": ClinicalTrials(NCT03592862: HTL0018318-203) (7/25)
¦AstraZeneca H1 and Q2 2018 Results: Clinical Trials Appendix Q2 2018 results update: Movement since Q1 2018 update: New to Phase I (Additional indications): "oleclumab+AZD4635 (CD73 mAb + A2aR inhibitor EGFRm NSCLC)". (7/26)
¦Pluristem: Granted Key Patent in Japan for Treatment of GI Following Acute Radiation Exposure. Recent data from Fukushima University shows PLX-R18 cells significantly increased survival and enhanced the recovery of the GI tract after radiation exposure. (7/26)
¦“ú–{ƒvƒƒZƒX‰»Šw‰ï2018ƒTƒ}[ƒVƒ“ƒ|ƒWƒEƒ€Fu‘a…«ƒ^ƒO‚ð—p‚¢‚½Icatibant Acetate‚̇¬v‹v•Û‘å•ã(JITSUBO) (7/27)
¦‚»[‚¹‚¢CVCFSosei RMF1 (Ķˆã—Ãtƒ@ƒ“ƒh)‚©‚çPromethera Biosciences SA ‚Ö‚Ì“ŠŽ‘‚ðŽÀsB(7/27)
¦‘å“ú–{Z—F»–ò2019”N3ŒŽŠú ‘æ1Žl”¼ŠúŒˆŽZB–k•ÄCOPDŽ¡—ÃÜ(“±“ü3»•i)F2018”N“x1QŽÀÑF2‰­‰~(2017”N“x1QŽÀÑ1‰­‰~)A‘Œ¸ŠzF0‰­‰~A‘Œ¸—¦29.5%(–k•ÄŒ»’n’ʉ݃x[ƒX‘Œ¸—¦31.9%)A2018”N“x2Q—ÝŒv—\‘zF10‰­‰~Ai’»—¦F15.3%A2018”N“x’ÊŠú—\‘zF29‰­‰~B(7/27)
¦‘å“ú–{Z—F»–ò2019”N3ŒŽŠú ‘æ1Žl”¼ŠúŒˆŽZƒJƒ“ƒtƒ@ƒŒƒ“ƒXƒR[ƒ‹‰¹º”zMF[Q&A2F–k•ÄCOPD“±“ü3•i–ڂɂ‚¢‚Ä]. (7/30up)
¦ClinicalTrials(NCT03381274): Phase 1b/2, Oleclumab(MEDI9447) EGFRm NSCLC Novel Combination Study. (MEDI9447 with Osimertinib or AZD4635, AZD4635 with MEDI9447). Research Site Status Change: California, Maryland: "Recruiting". Study Completion Change: "2021/12/14" (7/30update)
¦Heptares: We are now seeking to appoint an enthusiastic and motivated gIT Support T


825:echnicianh working in our expanding IT team. (7/30Closed) ¦JITSUBOF9ŒŽ21“ú‚É–k‚Æ‚Ò‚ (“Œ‹ž“s–k‹æ‰¤Žq)‚É‚ÄŠJ³‚¹‚Ü‚·Š”Ž®‰ïŽÐî•ñ‹@\ŽåẪZƒ~ƒi[‚É‚ÄA“–ŽÐEˆõ‚ªu‰‰(uƒyƒvƒ`ƒhŒ´–ò‚Ì»‘¢ƒvƒƒZƒXŠm—§‚Ü‚Å‚Ìl‚¦•û‚Æ‚»‚̃|ƒCƒ“ƒgvJITSUBO Œ¤‹†ŠJ”­•” •”’· ŽRú±‹MŽj)‚ðs‚¢‚Ü‚·B(7/31) ¦Imperial College London, Imperial Innovations: Graduation Ceremony of MiNA Therapeutics: "Robert Habib from MiNA Therapeutics receives the graduation award and shares company's journey since joining Imperial Incubator." (7/31) ¦•Ä‘“Á‹–oŠè(Jitsubo)FPeptide Synthesis Method. (8/2ŒöŠJ) ¦Miles Congreve (Heptares): My last day at BioPark, bring on Granta Park, Cambridge! (8/2) ¦SOSEIŠ”Žå’ÊMFu“ú–{‰‚Ì‘Û“I‚ȃŠ[ƒfƒBƒ“ƒOƒoƒCƒI»–òŠé‹Æ‚ð–ÚŽw‚µ‚ÄvF“–ŽÐ‚Í‘å‚«‚Ȭ’·‚ð‹‚°A“ú–{‰‚Ì‘Û“I‚ȃŠ[ƒfƒBƒ“ƒOƒoƒCƒI»–òŠé‹Æ‚Ö‚Ì“¹‚ð‡’²‚Éi‚ñ‚Å‚¢‚Ü‚·B2018”N3ŒŽŠú‚Í‚±‚ê‚Ü‚Å‚ÅÅ‚à‘å‚«‚Èi•à‚ð‹‚°‚½”N‚É‚È‚è‚Ü‚µ‚½B(8/6) ¦ŒÂ•ÊŠ”î•ñFSBIØŒ”‚Å‚ÍAHeptaresŠJ”­ƒpƒCƒvƒ‰ƒ“‚Ì’†’·Šú“I‚ÈŽ¡Œ±‚Ìi‚¿‚å‚­‚ÉŠú‘ÒB“¯ŽÐ‚ÌŽ–‹Æ‰¿’l‚ÍHeptares‚ÌŠJ”­ƒpƒCƒvƒ‰ƒCƒ“‚É‚ÄŒˆ‚Ü‚éB‚±‚ÌŠ”‰¿…€‚ÍAHeptaresƒpƒCƒvƒ‰ƒCƒ“‚ªŠJ”­‘O”¼í‚Å‚ ‚邱‚Æ‚ð‰Á–¡‚·‚é‚Æu“K³v‰¿Ši‚É—Ž‚¿’…‚¢‚Ä‚¢‚éB(8/6) ¦Heptares Twitter (Change Name): Heptares¨hSosei Heptaresh. (8/6 Changed)



826:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:16:50.37 I0K5AwPfa.net
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827:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:17:14.34 I0K5AwPfa.net
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828:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:19:25.07 pU+d6bVhp.net
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829:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:20:43.50 09FTXi540.net
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830:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:33:44.81 T/5MauaB0.net
¦‚ ‚·‚©»–ò •½¬31”N3ŒŽŠú‘æ1Žl”¼ŠúŒˆŽZFŽå—Í•i‚Ì”„ã‚F‹Ù‹}”ð”DÜ(ƒmƒ‹ƒŒƒ{)F“–Šú‘æ1Žl”¼Šú3.1‰­‰~(‘OŠú‘æ1Žl”¼Šú3.2‰­‰~)A‘ΑO”N“¯Žl”¼Šú‘Œ¸—¦¢1.6“A“–Šú”NŠÔŒ©ž12.6‰­‰~(‘OŠú”NŠÔŽÀÑ12.1‰­‰~) (8/6)
¦Medicinal Chemistry GRC: "Novel Adenosine 2A Receptor Antagonist AZD4635: From the Brain to the Tumor Microenvironment": Michelle Lamb, AstraZeneca USA. (8/6 Presented)
¦Oligonucleotide Therapeutics Society (OTS): The newest Paper of the Month is Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer. (8/6)
¦‰¢B“Á‹–(Sosei R&D)FTreatment of Respiratory Diseases. (8/8ŒöŠJ)
¦Pluristem Initiates Two Pivotal Phase III Studies in Israel. Numerous Clinical Sites in Israel to join sites in the U.S. and Europe for Pivotal Phase III Studies of PLX-PAD Cell Therapy in the Treatment of Critical Limb Ischemia and Muscle Injury Following Hip Fracture. (8/8)
¦SOSEI 2018”N12ŒŽŠú‘æ1Žl”¼ŠúŒˆŽZFŒ¤‹†ŠJ”­”ï1,826•S–œ‰~(69.5“‘‰Á) 97.3%‚͉p‘Šˆ“®Bƒvƒ‰ƒbƒgƒtƒH[ƒ€‚ðˆø‚«‘±‚«Šg[B“–ŽÐƒOƒ‹[ƒv‚Í13•i–Ú‚ª‘n–ò’iŠKA5•i–Ú‚ª‘O—Õ°ŽŽŒ±’†A4•i–Ú(ƒŒƒr[¬‘ÌŒ^”F’mÇ(DLB)Š³ŽÒ‚ð‘ÎÛ‚Æ‚µ‚½“ú–{‚É‚¨‚¯‚éMATILDA‘OŠú‘æ‡U‘ŠŽŽŒ±‚ðŠÜ‚Þ)‚ª—Õ°ŽŽŒ±’†B(8/9)
¦ƒyƒvƒ`ƒhƒŠ[ƒ€ •½¬30”N6ŒŽŠúŒˆŽZFPAR2‚ɑ΂µA‚‚¢e


831:˜a«‚Æ‘I‘ð«‚ð—L‚·‚éƒyƒvƒ`ƒhEƒAƒ“ƒ^ƒSƒjƒXƒg‚𓯒肵‚Ä‚¨‚èA‚±‚̃vƒƒOƒ‰ƒ€‚ÍŒ»ÝAHit-to-Lead‚̃Xƒe[ƒW‚É“ü‚Á‚Ä‚¨‚è‚Ü‚·B(8/9) ¦JITSUBOF“–ŽÐ‹Zp‚ÉŠÖ˜A‚·‚é˜_•¶‚ð’ljÁ‚µ‚Ü‚µ‚½BˆÈ‰º(“–ŽÐ‹ZpŠÖ˜A˜_•¶ƒy[ƒW)‚æ‚育Šm”F‚­‚¾‚³‚¢B(8/9) ¦•Ä‘“Á‹–oŠè(Heptares)FMuscarinic Agonists. (8/9ŒöŠJ)



832:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:34:20.21 T/5MauaB0.net
¦ClinicalTrials(NCT03592862: HTL0018318-203): Phase 2, A Study to Assess Safety, Tolerability, and Efficacy of HTL0018318 in Patients With Dementia With Lewy Bodies (DLB). Locations(Add, Study Research Site):‚­‚é‚݃NƒŠƒjƒbƒN: "Recruiting", Tokyo, Japan. (8/9update.)
¦Žl‹G•ñƒIƒ“ƒ‰ƒCƒ“Fˆã–ò¥ƒoƒCƒIƒxƒ“ƒ`ƒƒ[‚Ì•]‰¿‚ʼn½‚ªd—v‚©B‰Ÿ‚¦‚Ä‚¨‚­‚ׂ«3‚‚̃|ƒCƒ“ƒgB‚»[‚¹‚¢ƒOƒ‹[ƒvFˆêŽž‹à‚Ì”—ŽŒã‚Í‹ÆÑ‚ª’á–ÀBŠé‹Æ”ƒŽû‚ɑ΂·‚é–Ú—˜‚«—Í‚Í‚‚­•]‰¿‚³‚ꂽ‚à‚Ì‚ÌA“ÆŽ©ŠJ”­‚Í‚±‚ê‚©‚çA¡ŒãA–{“–‚̈Ӗ¡‚Å‚ÌŠJ”­—Í‚ª–â‚í‚ê‚é‹Ç–Ê‚É“ü‚Á‚Ä‚¢‚­B(8/13)
¦ClinicalTrials(NCT03592862: HTL0018318-203): Phase 2, A Study to Assess Safety, Tolerability, and Efficacy of HTL0018318 in Patients With Dementia With Lewy Bodies (DLB). Change Study Status: Not yet Recruiting¨"Recruiting". (8/13update.)
¦Vaccinex: Form 10-Q(SEC Filings): hCollaboration Agreements: hIn June 2018, the Company entered into a research service agreement with Heptares Therapeutics, Ltd. to provide research services to Heptares. (8/14)
¦ƒƒ‹ƒgƒŒF‚»[‚¹‚¢“ŠŽ‘æsƒoƒCƒIŠé‹ÆAƒŒƒr[¬‘ÌŒ^”F’mÇ—Õ°ŽŽŒ±‚É’–ÚBHTL18318‘“àPhase2ŽŽŒ±‚ªŠÔ‚à‚È‚­ŠJŽn‚³‚ê‚é‚Æ‚Ìl‚¦‚É•ÏX‚ª–³‚¢‚ƃŒƒ|[ƒg‚ʼnðàBŒˆŽZ”­•\‚ÍŒ¤‹†ŠJ”­“ŠŽ‘æs‚̃oƒCƒIŠé‹Æ‚Å‚ ‚茈ŽZ‚ɃTƒvƒ‰ƒCƒY‚Í‚È‚­AƒoƒCƒIŠé‹Æ‚ð‘«Œ³‚Ì‹ÆÑ‚Å”»’f‚·‚é‚Ì‚Í“KØ‚Å‚Í‚È‚¢‚Æ‚àà–¾B(8/15)
¦ƒtƒBƒXƒRFŒÂl“ŠŽ‘‰ÆŠ”ŽtE–¾F2018”Nƒm[ƒxƒ‹ÜŒó•â‚©‚ç˜A‘z‚³‚ê‚éƒm[ƒxƒ‹ÜŠÖ˜A–Á•¿‚Æ‚ÍH ‚»[‚¹‚¢ƒOƒ‹[ƒvFEƒoƒCƒIƒxƒ“ƒ`ƒƒ[‚Æ‚µ‚Ä“ŒØƒ}ƒU[ƒYŽsê‚Å‘å‚«‚È‘¶ÝŠ´‚ðŽ¦‚µ‚Ä‚¢‚éBŒ¤‹†ŠJ”­‚É—Í‚ð“ü‚ê‚邪‚ñŽ¡—Öò‚È‚Ç‚ÉŠÖ˜A‚·‚錤‹†‚ªƒm[ƒxƒ‹Ü‚ðŽóÜ‚·‚ê‚ÎA‘‚È‚Ç‚É‚æ‚éŒã‰Ÿ‚µ‚ÉŠú‘Ò‚µ‚â‚·‚­‚È‚éB (8/15)
¦Œú¶˜J“­ÈF–òŽ–EH•i‰q¶R‹c‰ï ˆã–ò•i‘æ“ñ•”‰ï‚ð(8/29 14:00`17:00)ŠJµ‚Ü‚·B(‹c‘èFm•ñŽ–€nˆã–ò•iƒIƒ‰ƒrùŒûo—p50mg‚Ì»‘¢”Ì”„³”F‚ɂ‚¢‚Ä)B(8/15up)
¦ClinicalTrials(NCT03592862: HTL0018318-203): Phase 2, A Study to Assess Safety, Tolerability, and Efficacy of HTL0018318 in Patients With Dementia With Lewy Bodies (DLB). Add, Study Research Site: å‘休½‰ê•a‰@: "Recruiting", Sendai. 쌧—§’†‰›•a‰@: "Recruiting", Takamatsu. (8/15update)

833:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:34:43.09 T/5MauaB0.net
¦•Ä‘“Á‹–oŠè(Heptares)F"Muscarinic Agonists". (8/16ŒöŠJ)
EDocument Type and Number: United States Patent Application 20180228791 A1
EPublication Date: 2018/8/16
EAssignee: Heptares Therapeutics Limited
Abstract:
This invention relates to compounds that are agonists of the muscarinic M4 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases.
Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.
Compounds include those according to formula 1a or a salt thereof, wherein n, p, Q, R1, R2, R3, R9 and R4 are as defined herein.
URLØݸ(www.freepatentsonline.com)

834:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:38:01.13 T/5MauaB0.net
EEE
¦ACS National Meeting - GPCR Symposium: "SBDD for GPCRs & Other Difficult Targets": Session Organizers: Chris de Graaf, Heptares. (8/21 13:30 Presiders)
¦ACS National Meeting - GPCR Symposium: "Navigating structural GPCR-ligand interaction space for crafted computer-aided drug design": Chris de Graaf, Heptares. (8/21 1


835:4:50 Presenting) ¦EFMC International Symposium on Medicinal Chemistry: Chris de Graaf, Heptares. (9/2-6) ¦EFMC International Symposium on Medicinal Chemistry: Breakthroughs in Polypharmacology Towards Neurological Disorders(ACS Session): "In silico Polypolpharmacology": Giovanni Bottegoni, Heptares. Invited Speakers. (9/4 14:50 Presenting) ¦Annual CCPBioSim Meeting: Molecular Simulations in Drug Discovery and Development: (Invited Speakers): Chris de Graaf, Heptares. (9/5-7) ¦SCI/RSC Symposium on GPCRs in Medicinal Chemistry: "Keynote: Application of structure-based drug design to peptidergic GPCRs": Miles Congreve, Heptares. (9/10 14:50 Presenting) ¦Pluristem FY 2018 Earnings Release: (9/10 Projected) ¦Vectura Interim Results for the six-month period ending 30 June 2018: (9/11) ¦SCI/RSC Symposium on GPCRs in Medicinal Chemistry: "Mining structural GPCR-ligand interaction maps to navigate medicinal chemistry space": Chris de Graaf, Heptares.(9/11 10:20 Presenting). ¦SCI/RSC Symposium on GPCRs in Medicinal Chemistry: "Keynote: Shedding light on G protein bias: structures of GPCRs coupled to G proteins determined by cryo-EM and X-ray crystallography": Chris Tate, MRC LMB. (9/12 9:30 Presenting) ¦Žl‹G•ñ 2018”N4WEH†F9ŒŽ14“ú”­”„(XV) (Žl‹G•ñæŽæ‚èF9ŒŽã{) ¦ILCA Annual Conference, London, UK: MiNA Therapeutics. (9/14-16) ¦European Symposium on Quantitative Structure-Activity Relationships (EuroQSAR) 2018: Jon Mason, Heptares. (9/16-20)



836:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 18:38:21.95 T/5MauaB0.net
¦ç—¢ƒ‰ƒCƒtƒTƒCƒGƒ“ƒXƒZƒ~ƒi[uƒAƒ‹ƒcƒnƒCƒ}[•aŒ¤‹†‚ÌÅ‘OüvFuƒAƒ‹ƒcƒnƒCƒ}[•a‚Æ‚¢‚¤complex disease‚ð‚Ç‚¤U‚ß‚é‚©FA mouse-to-human translational researchv‘åã‘åŠw‘åŠw‰@ ˆãŠwŒnŒ¤‹†‰È ˆãŠw•”uŽt (Šñ•uÀ‹³Žö) XŒ´„Žj (9/19 11:00)
¦ç—¢ƒ‰ƒCƒtƒTƒCƒGƒ“ƒXƒZƒ~ƒi[uƒAƒ‹ƒcƒnƒCƒ}[•aŒ¤‹†‚ÌÅ‘OüvFuƒAƒ‹ƒcƒnƒCƒ}[•a‚ÌŽ¡—Ãí—ª‚ɑ΂·‚é“´Ž@F‘ÎǗÖ@‚⑼‚Ì”F’mÇ«Ž¾Š³‚Ì—Õ°ŽŽŒ±‚ðƒ‚ƒfƒ‹‚Æ‚µ‚Ävs“®_ŒoŠwE_Œo¸_ˆãŠw(Heptares)Šñ•uÀ‹³Žö X‰x˜Y (9/19 14:10)
¦Š”Ž®‰ïŽÐî•ñ‹@\ƒZƒ~ƒi[Fuƒyƒvƒ`ƒhŒ´–ò‚Ì»‘¢ƒvƒƒZƒXŠm—§‚Ü‚Å‚Ìl‚¦•û‚Æ‚»‚̃|ƒCƒ“ƒgvJITSUBO Œ¤‹†ŠJ”­•” •”’· ŽRú±‹MŽj (9/21 13:30-16:30)
¦Rhine-Knee Regional Meeting on Structural Biology, Switzerland: Scientific Program Keynote Speakers: Dr. Andy Dore, Heptares Therapeutics. (9/26-28)
¦OTS(Oligonucleotide Therapeutics Society) Annual Meeting 2018, Seattle, WA, USA: MiNA Therapeutics. (9/30-10/3)
¦Fragment-based Lead Discovery Conference 2018: "Keynote Lecture: Discovery of Modulators of GPCRs using Fragment-Based Drug Discovery": Miles Congreve, "Sosei Heptares". (10/9 11:20 Presenting) ¦8/1update
¦ELRIG Drug Discovery 2018, London: "Targeting the Reward System in Addiction - Structure-Based Drug Design of Selective Orexin 1 Receptor Antagonist": Kirstie Bennett, Heptares. (10/9 12:00 Presenting)
¦The UK Biopharma Research & Development Summit, London: Malcolm Weir, Founder, Chairman and CEO, Heptares. (10/10 13:00-18:00 Panelists) ¦8/15up
¦Schrodinger Life Science User Meeting 2018, Boston: Jon Mason, Heptares Therapeutics. (10/25 9:15 Presenting) ¦8/11up
¦BIO-Europe, Copenhagen, Denmark: MiNA Therapeutics. (11/5-7)
¦AASLD Liver Meeting 2018, San Francisco: MiNA Therapeutics. (11/9-13)
¦Jefferies London Healthcare Conference, London, UK: MiNA Therapeutics. (11/14-15)
¦PCT (Partnerships in Clinical Trials) Europe: "Use of molecular and functional Imaging in early clinical development: From target engagement to proof of concept": Pradeep Nathan, Heptares. (11/29 15:00 Presenting)
¦PREP UK 2018: Organising Committee: Kerry O'Hare (Lead Analytical and Purification Chemist, Heptares). (11/29-30)
EEE

837:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:12:37.89 wR67KXgmV
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839:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:26:55.80 7w49U1T/0.net
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840:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:28:23.44 Ga1suTmP0.net
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841:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:35:41.05 wR67KXgmV
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842:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:40:58.90 wR67KXgmV
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843:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:44:37.61 wR67KXgmV
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844:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:50:29.28 wR67KXgmV
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845:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 20:59:49.03 wR67KXgmV
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846:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 21:04:04.30 wR67KXgmV
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847:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 22:00:09.16 T/5MauaB0.net
¦SOSEI‚̬’·‘Šê‚Ì“®ŒüF[Š”Ž®4•ªŠ„F6/27•ªŠ„”ä—¦C³Ï]
2010/12/30 (I’l_338) E(2010/10/15¦ÅˆÀ’l_163A2010/12/27Å‚’l_437)
2011/12/30 (I’l_318) E(2011/_3/15¦ÅˆÀ’l_173A2011/_6/30Å‚’l_420)
2012/12/28 (I’l_522) E(2012/_6/_6¦ÅˆÀ’l_238A2012/_9/_7Å‚’l_742)
2013/12/30 (I’l1079) E(2013/_1/_4¦ÅˆÀ’l_513A2013/_5/_7Å‚’l1525)
2014/_4/25 (I’l_515) ”„Žc‚144800 ”ƒŽc‚_4212800 E(2014/_4/22ňÀ’l_464)¦[¬’·‰ñŽûŠú‚Ì“üŒû]ƒXƒe[ƒW‚Ö
2015/_2/20 (I’l_945) ”„Žc‚_56800 ”ƒŽc‚_6123200 E(2015/_3/16ňÀ’l_713)¦Heptares [¬Œ÷‚̘̓Xƒe[ƒW]
2015/10/30 (I’l1080) ”„Žc‚_45600 ”ƒŽc‚_8871600 E(2015/_9/24ˆÀ’l_888)¦•Ä‘³”F[ŽŸ‚È‚é”ò–ôƒXƒe[ƒW‚Ö]¦[㔲‚¯Œ—‚Ö]
2016/_4/25 (I’l5808) ”„Žc‚159200 ”ƒŽc‚13619600 E(2016_5/_9Å‚’l6545)¦Allergan[‹­‹C‘Šê]
2016/_6/24 (I’l3680) ”„Žc‚_42000 ”ƒŽc‚_9944400 E(2016/_6/24ˆÀ’l3240)¦[‹­‹C‘Šê‰ðœ]¦[ŽžŠÔŽ²‚Å‚Ì’²®‹Ç–Ê‚Ö]
2017/_3/31 (I’l2720) ”„Žc‚_22400 ”ƒŽc‚10487200 E(2017/_4/_4ˆÀ’l2570)¦[ŽžŠÔŽ²’²®‚͇’²‚É„ˆÚ]¦[U‚é‚¢êEE‚¢ê‚Ö]
2017/_9/_8 (I’l2175) ”„Žc‚__7600 ”ƒŽc‚_8151200 E(2017/_9/_6ňÀ’l2147)¦[E‚¢ê‚à‡’²‚É„ˆÚ]
2018/_1/26 (I’l3053) ”„Žc‚__3600 ”ƒŽc‚_5716400 E(1/22ˆÀ’l2740)¦[U‚é‚¢‚à‡’²‚É„ˆÚ]

848:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 22:00:25.34 T/5MauaB0.net
2018/_3/_9 (I’l2378) ”„Žc‚_42000 ”ƒŽc‚_7177600 E(3/_5ˆÀ’l2195)¦[ˆ«’n‡‚¢‚É‚ÄÄ‚Ñ‚ÌE‚¢ê‚Ö]
2018/_3/16 (I’l2268) ”„Žc‚_54000 ”ƒŽc‚_8079600 E(3/16ˆÀ’l_2


849:268) 2018/_3/23 (I’l2148) ”„Žc‚_56400 ”ƒŽc‚_8186000 E(3/23ˆÀ’l_2145) 2018/_3/30 (I’l2205) ”„Žc‚_57600 ”ƒŽc‚_8112000 E(3/26ˆÀ’l2080) 2018/_4/_6 (I’l2203) ”„Žc‚_68000 ”ƒŽc‚_7926000 E(4/_3ˆÀ’l2138) 2018/_4/13 (I’l1960) ”„Žc‚_61600 ”ƒŽc‚_8320800 E(4/13ˆÀ’l1943) 2018/_4/20 (I’l1820) ”„Žc‚_60400 ”ƒŽc‚_8460800 E(4/20ˆÀ’l1815) 2018/_4/27 (I’l1895) ”„Žc‚_70800 ”ƒŽc‚_8453600 E(4/23ˆÀ’l1803) 2018/_5/11 (I’l1760) ”„Žc‚_84800 ”ƒŽc‚_8396800 E(5/11ˆÀ’l1665)¦(5/11‹ó”„‚艿Ši‹K§ƒgƒŠƒK[’ïG) 2018/_5/18 (I’l1900) ”„Žc‚_78800 ”ƒŽc‚_8188800 E(5/14ˆÀ’l1745) 2018/_5/25 (I’l1793) ”„Žc‚_78000 ”ƒŽc‚_8364400 E(5/25ˆÀ’l1780) 2018/_6/_1 (I’l1838) ”„Žc‚_92000 ”ƒŽc‚_8324000 E(5/29ˆÀ’l1695) 2018/_6/_8 (I’l1700) ”„Žc‚104800 ”ƒŽc‚_8714800 E(6/_7ˆÀ’l1618)¦(6/_5‹ó”„‚艿Ši‹K§ƒgƒŠƒK[’ïG) 2018/_6/15 (I’l1713) ”„Žc‚_92000 ”ƒŽc‚_8482000 E(6/11ˆÀ’l1703) 2018/_6/22 (I’l1693) ”„Žc‚___400 ”ƒŽc‚_8232800 E(6/20ˆÀ’l1595)



850:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/16 22:00:46.53 T/5MauaB0.net
2018/_6/29 (I’l1784) ”„Žc‚_____0 ”ƒŽc‚_7931600 E(6/26ˆÀ’l1663)
2018/_7/_6 (I’l1387) ”„Žc‚__7300 ”ƒŽc‚_7728300 E(7/_5ˆÀ’l1304) ¦‹ó”„‚艿Ši‹K§ƒgƒŠƒK[(7/2ˆÀ’l1584, 7/3ˆÀ’l1414)
2018/_7/13 (I’l1412) ”„Žc‚__6800 ”ƒŽc‚_7479600 E(7/11ˆÀ’l1342)
2018/_7/20 (I’l1329) ”„Žc‚_10700 ”ƒŽc‚_7489500 E(7/20ˆÀ’l1308)
2018/_7/27 (I’l1422) ”„Žc‚__6600 ”ƒŽc‚_7579800 E(7/23ˆÀ’l1325)
2018/_8/_3 (I’l1369) ”„Žc‚__6600 ”ƒŽc‚_7358300 E(8/_2ˆÀ’l1366)
2018/_8/10 (I’l1369) ”„Žc‚__6600 ”ƒŽc‚_7101500 E(8/_8ˆÀ’l1366)
2018/_8/13 (I’l1255) 5“úü˜¨—£(-7.31“) 25“úü˜¨—£(_-9.09“) 75“úü˜¨—£(-23.02“) 200“úü˜¨—£(-42.92“) (ˆÀ’l1250)
2018/_8/14 (I’l1237) 5“úü˜¨—£(-6.30“) 25“úü˜¨—£(_-9.94“) 75“úü˜¨—£(-23.76“) 200“úü˜¨—£(-43.58“) (ˆÀ’l1213)
2018/_8/15 (I’l1225) 5“úü˜¨—£(-5.11“) 25“úü˜¨—£(-10.32“) 75“úü˜¨—£(-24.08“) 200“úü˜¨—£(-43.96“) (ˆÀ’l1205)
2018/_8/16 (I’l1214) 5“úü˜¨—£(-3.65“) 25“úü˜¨—£(-10.69“) 75“úü˜¨—£(-24.33“) 200“úü˜¨—£(-44.29“) (ňÀ’l1185)¦[”N‰—ˆˆÀ’lXV]
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18/08/16 22:12:43.97 leiAa+ux0.net
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18/08/16 22:47:43.88 qbfzOlS50.net
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18/08/16 23:15:06.02 SWbBaC1ga.net
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18/08/16 23:43:51.91 pU+d6bVhp.net
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18/08/17 00:20:12.75 1NN3erAAr.net
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18/08/17 00:21:15.00 ocfezDwna.net
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18/08/17 00:30:06.24 BBn710d8w
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18/08/17 00:32:30.50 ocfezDwna.net
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18/08/17 00:36:19.61 1NN3erAAr.net
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18/08/17 00:42:50.67 1NN3erAAr.net
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18/08/17 02:55:32.55 H+j5tjaVd.net
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864:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 05:50:18.09 XYmUYACPp.net
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865:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:03:02.78 1WBY8Zjw0.net
Allergan (M Series):
EEE
¦ClinicalTrials: HTL0018318-105: Phase 1, Pharmacokinetics of Oral Capsule in Healthy Japanese vs. Caucasian Subjects. Actual Start: 2017/5/16, Completion: 2017/8/15. "New Trial Record Entry". (2017/6/25up,"New Trial Record")
¦Allergan Q2 2017 Presentation: Pipeline Highlights: "Muscarinic Receptor M1 and M4 Agonist: Ph 1, 2H 2017; Entry Ph 1, 2H 2017; Rspectively." (2017/8/3Changed)
¦Netherland Trials: HTL0018318-101(NTR5648) "Trial Finished", ¦HTL0018318-102(NTR5781) "Trial Finished", ¦HTL0018318- CHDR162 (NTR619) "Trial Finished". (2017/8/5:Completed. 2017/8/8update)
¦ClinicalTrials: HTL0016878-101: Phase 1, A Two Part Study to Assess Safety, PK, PD, and Food Effect of Oral HTL0016878. Star: 2017/8/7. Study Completion: 2018/9. "New Trial Record Entry". (2017/8/8up,"New Trial Record")
¦SOSEIFƒAƒ‹ƒcƒnƒCƒ}[•a“™Ž¡—Öò‚Æ‚µ‚ÄŠJ”­’†V–òŒó•âA‘I‘ð“Iƒ€ƒXƒJƒŠƒ“M4Žó—e‘Ìì“®–ò‚Ì‘æI‘Š—Õ°ŽŽŒ±‚Åʼn‚̔팱ŽÒ‚Ö‚Ì“Š—^ŽÀŽ{B15•S–œ•Äƒhƒ‹Žó—ÌB—Õ°ŽŽŒ±Œ‹‰Ê‚Ì‘¬•ñ‚Í2018”NãŠú—\’èB(2017/9/1)
EƒAƒ‹ƒcƒnƒCƒ}[•aŠ³ŽÒ‚ÌÇŒó«”F’máŠQ‚ÌŽ¡—ÖòŒó•â‚Å‚ ‚é‘I‘ð“IM1Žó—e‘Ìì“®–ò‚ð•]‰¿‚·‚éƒvƒƒOƒ‰ƒ€‚ð—Õ°ŽŽŒ±‚É‚æ‚Á‚Äi‚ß‚Ä‚¨‚è
EX‚ÉA”F’mÇó‹y‚Ñs“®“IÇó‚Ì—¼•û‚ÌŽ¡—ÖòŒó•â‚Æ‚µ‚ÄM1/ M4ƒfƒ…ƒAƒ‹Žó—e‘Ìì“®–ò‚ðŠJ”­‚·‚邽‚ß‚É‘O—Õ°ŽŽŒ±‚ÉŽæ‚è‘g‚ñ‚Å‚¢‚Ü‚·B
¦ClinicalTrials: HTL0018318-105: Phase 1, Pharmacokinetics of Oral Capsule in Healthy Japanese vs. Caucasian Subjects. "Actual Study Completion: 2017/8/20." (2017/9/7update, "Completed")
¦ClinicalTrials: HTL0016878-101: Phase 1, A Two Part Study to Assess Safety, PK, PD, and Food Effect of Oral HTL0016878. "Recruiting: Actual Study Start: 2017/8/25.", Estimated Study Completion: 2018/9. (2017/9/7update)
¦Heptares: Corporate Overview September 2017. (2017/9/27update)
EM1 Agonist - HTL009936/HTL0018318: First-In-Class Oral Agents in Phase 1 Clinical Studies. "Planning Underway for Studies in AD Patients"
EM4 Agonist - HTL0016878 - Highly Selective for M4, optimised pharmacology: Phase 1 Study Initiated in Healthy Subjects.
EDual M1/M4 Agonists - Cognitive impairment & neurobehavioural symptoms: In Preclinical Stage.
EWave 1 Partnered Pipeline: M1, Progression 2017-2019: "Start of Phase 2 POC Trial in AD Patients", "AD PoC Results Emerging"
EWave 1 Partnered Pipeline: M4, Progression 2017-2019: "Start of Phase 1 Trial", "Phase 1 Results", "Progression to PoC Studies"
EWave 1 Partnered Pipeline: M1/M4 dual, Progression 2017-2019: "Start of Phase 1 Trial"

866:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:03:19.94 1WBY8Zjw0.net
¦ClinicalTrials(NCT03316898): A FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil}Memantine) for the Treatment of Participants with Mild to Moderate Alzheimer's Disease: Ph1b. (2017/10/21up, "New Trial Record")
E(Protocol ID: 3142-101-001. Sponsors and Collaborators: Allergan), (Study Locations: United States.)
¦Allergan Q3 2017: Pipeline Highlights 2017: Muscarinic Receptor M1: Ph 1, 2H 2017 and M4 Agonist: Entry Ph 1, 2H 2017. Rspectively: "Achieved". (2017/11/1)
¦SOSEIFƒŒƒr[¬‘ÌŒ^”F’mÇŠ³ŽÒ‚ð‘ÎÛ‚Æ‚·‚éHTL0018318‚Ì“ú–{—Õ°ŠJ”­ŠJŽnB’ñŒgŒ_–ñ‚ðŽå—v‚È”F’mÇ‚ð’ljÁ³”FŽæ“¾‚·‚é‰ü’èBŒ¤‹†ŠJ”­‹¦—Í•ª–ì‚ðŠg‘åB2018”N‚ÉPh2 POCŽŽŒ±ŠJŽn—\’èB(2017/11/9)
¦SOSEI‘æ2Žl”¼ŠúŒˆŽZFŒ¤‹†ŠJ”­”ï(94.6“‚͉p‘)‘‰ÁBŠJ”­‘£i‚Ì‚½‚ß‚Ì—Õ°ŠJ”­•À‚тɃgƒ‰ƒ“ƒXƒŒ[ƒVƒ‡ƒiƒ‹ˆã—Â̊g‘åEŠg’£‚ÖŒü‚¯‚½Žæ‘g‚ÝB–ˆ”N•½‹Ï3•i–ڂ̉»‡•¨—Õ°“ü‚èB(2017/11/9)
¦SOSEI‘æ2Žl”¼ŠúŒˆŽZà–¾‰ï(2017/11/9)FƒpƒCƒvƒ‰ƒCƒ“ŠJ”­i’»ó‹µBà–¾‰ï(‰¹º)F Q&A (HTL009936 ‘¼“K‰ž‚ð’Tõ)B(2017/11/14up)
EM1 ADFƒAƒ‹ƒcƒnƒCƒ}[Œ^”F’mÇŠ³ŽÒ‚ð‘ÎÛ‚É‚µ‚½‘I‘ð“IM1Žó—e‘Ìì“®–ò‚ÌPh1b‚ðŠJŽnBHTL0018318‚Í‘¼‚Ì•¨Ž¿Œó•âŒQ‚É”ä‚ׂėÇD‚ȃvƒƒtƒ@ƒCƒ‹B(New)
EM4 SZFƒtƒ@[ƒXƒgEƒCƒ“EƒNƒ‰ƒX‚Ì‘I‘ð“IM4Žó—e‘Ìì“®–ò‚Å‚ ‚éHTL0016878‚ÌPh1‚É‚¨‚¢‚ÄŒ’Nl‚ւ̉“Š—^‚ðŽÀŽ{Bƒ}ƒCƒ‹ƒXƒgƒ“Žû“ü15•S–œƒhƒ‹‚ðŽó—Ì(9/1)B
EM1 DLBF“ú–{‚É‚¨‚¯‚éDLBŠJ”­E”Ì”„Œ ‚ðŠl“¾B2018”N’†‚ÉPh2a POCŽŽŒ±(’PÜ“Š—^)‚ðŠJŽn—\’èB“ú–{‘“à‚É‚¨‚¯‚黑¢”Ì”„³”F\¿•À‚Ñ‚ÉãŽs‚ð–ÚŽw‚·B(New)
¦ClinicalTrials(NCT03316898): Phase 1b, FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil } Memantine): Change Start: 2017/11/28¨"2018/2/20", Change Completion: 2018/6/4¨"2018/11/4". (1/12update)
¦SOSEI (English) Presentation Material: (J.P. Morgan Healthcare Conference: 1/8). (1/16up)
EHTL0018318 (AD): Same Compound Being Advanced by Allergan for AD in Our Partnered Pipeline. "Phase 1b"
EHTL0018318 (DLB): Phase 2 POC Monotherapy Study, Expected to Begin in Japan in 2018. "Phase 2 Ready"
¦SOSEIŠ”Žå’ÊMFí—ª–Ê‚Å‚ÍA“–ŽÐƒrƒWƒlƒXEƒpƒCƒvƒ‰ƒCƒ“‘o•û‚ð‹­‰»‚·‚é“ŠŽ‘‚ÆŒðÂ‚ðŠ®—¹‚µ‚½‚¾‚¯‚Å‚È‚­AŠCŠO‚É‚¨‚¯‚鎑‹à’²’B‚É‚¨‚¢‚Ä‚à‘å‚«‚ȬŒ÷‚ðŽû‚ß‚Ü‚µ‚½BƒrƒWƒlƒX‚Ö‚Ì“ŠŽ‘‚ÆŠg‘åB(2/2)
¦Allergan Q4 and FY 2017: Pipeline Highlights 2017: Muscarinic Receptor M1: Ph 1, 2H 2017 and M4 Agonist: Entry Ph 1, 2H 2017. Rspectively: "Achieved". FY 2017 R&D Milestones: $15m. (2/6)
¦SOSEŒˆŽZFŒ¤‹†ŠJ”­”ï3,456•S–œ‰~(48.4“‘‰Á)97.1%‚͉p‘Šˆ“®B“ú–{‚É‚¨‚¯‚éHTL0018318(DLB)‚Ì—Õ°ŽŽŒ±ŠJŽn‚ÉŒü‚¯‚½€”õ‚ðŠÜ‚ßAŽ©ŽÐ“ÆŽ©‚̃pƒCƒvƒ‰ƒCƒ“Šg‘å‚ÉŒü‚¯‚½“ŠŽ‘‚àŒp‘±‘‰ÁB(2/14)
¦Allergan: Management's and Analysis: Long-term Obligations: Heptares Transaction: (Maximum Milestones: $ 3,224.5m, R&D / Approval: $ 649.5m, Sales Based and Other Milestones: $ 2,575m). (2/16)

867:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:03:50.62 1WBY8Zjw0.net
¦ClinicalTriasls(NCT03456349): A Phase 1b, Multi-center Study to Determine the Safety and Tolerability of HTL0018318 in Subjects with AD. "Actual Start: 2017/11/10". Estimated Completion: 2018/8. (3/7up, "New Trial Record")
E(Protocol ID: HTL0018318-202. Sponsors: Heptares. Collaborators: Allergan.), (Study Locations: Czechia: Recruiting, Poland: Recruiting, Slovakia: Recruiting, Spain: Recruiting.)
¦Allergan Fact Sheet: This is Allergan: Our Open Science Pipeline(50¨70 mid-to-late stage programs): CNS(10¨13 programs): Alzheimerfs disease: (M1 Agonist, M4 Agonist, M1/M4 Agonist). (3/9 update)
¦SOSEIŒÂl“ŠŽ‘‰Æà–¾‰ïFƒŒƒr[¬‘ÌŒ^”F’mÇ‚ð“K—p‚Æ‚µ‚½HTL001831‚ÌŠJ”­(“ú–{)FƒeƒBƒ€Eƒ^ƒXƒJ[A\‘¢¶•¨Šw‹y‚ÑŒ¤‹†ŠJ”­ƒpƒCƒvƒ‰ƒCƒ“‚ɂ‚¢‚ÄFƒ}ƒ‹ƒRƒ€EƒEƒBƒA[B(3/14)
EHTL0018318(AD)F2‚‚̑æ1‘ŠŒãŠúŽŽŒ±(Allergan Phase 1b)F‰¢BF2017”N‚ÉŠ³ŽÒ“Š—^ŠJŽn (Protocol: HTL0018318-202is’†)B•Ä‘F¡Œã”ƒ•ŒŽ“à‚ÉŠ³ŽÒ“Š—^ŠJŽn—\’è (NCT03316898: Protocol 3142-101-001)B
EHTL0018318 (DLB)F‘æ1‘Š‘OŠúŽŽŒ±‚Å‚ÍA‚—îŽÒ‚ðŠÜ‚ßAˆÀ‘S‚©‚”E—e«‚ª—ÇD‚Å‚ ‚邱‚Æ‚ªŽ¦‚³‚ꂽB2018”N’†‚É“ú–{‚É‚¨‚¯‚郌ƒr[¬‘ÌŒ^”F’mÇ‚ð‘Γ™‚Æ‚µ‚½‘æ‡U‘Š—Õ°ŽŽŒ±(PoC)ŠJŽn‚ð–ÚŽw‚·B
EHTL0016878FAD‚Ì_Œos“®Šw“IÇóF‘æ1‘ŠŽŽŒ±’iŠK(Allergan Phase 1)FHTL16878‚ðʼn‚̔팱ŽÒ‚Å‚ ‚錒íl‚É“Š—^‚µ‚½‚±‚Æ‚ðŒö•\(2017/9/1)B(Œ‹‰Ê‘¬•ñ‚Í2018”NãŠú‚É“¾‚ç‚ê‚é—\’èjB
¦ClinicalTrials(NCT03316898): Phase 1b, FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil}Memantine) for the Treatment of Participants with Mild to Moderate AD. Change Start: 2/20¨"2018/4/13". (3/14update)
¦ClinicalTrials(NCT03316898): Phase 1b, FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil}Memantine) for the Treatment of Participants with Mild to Moderate AD. Change Start: 4/13¨"2018/5/20". (4/17update)
¦Allergan Q1 2018FAs a leader in the field of symptomatic improvement to work. We have the deal with Sosei-Heptares. Symptomatic improvement is one of our core areas of R&D within Allergan. (4/30)
¦Allergan Management's Analysis: "Transaction: Heptares". Product: "Neurological disorders". Maximum Milestones: "$ 3,224.5m". R&D/Approval Milestones: "$ 649.5m". Sales Based and Other Milestones: "$ 2,575.0m". (5/3)
¦SOSEI 2018”N3ŒŽŠúŒˆŽZFŒ¤‹†ŠJ”­”ï4,818•S–œ‰~(54“‘‰Á)97%‚͉p‘Šˆ“®B–ˆ”N3‚‚ÌV–òŒó•â‚ð”


868:­Œ©‚·‚éPresenting‚±‚Æ‚ª‚Å‚«‚éƒvƒ‰ƒbƒgƒtƒH[ƒ€\’zB“–ŽÐ“ÆŽ©‚̉»‡•¨ŠÖ˜AƒpƒCƒvƒ‰ƒCƒ“‚ª‘å•‚Éi“WBŽ©ŽÐŠJ”­•iŠg[B(5/10) ¦SOSEIŒˆŽZà–¾‰ïFuí—ªƒvƒ‰ƒ“‚ð’…ŽÀ‚ÉŽÀs‚µ2017”N“x‚Í’˜‚µ‚¢i’»‚ð’B¬vBŽ–‹Æ‚ÍŒ˜’²‚Éi’»BƒrƒWƒlƒXƒ‚ƒfƒ‹3‚‚̒ŒFƒŠƒXƒN’ጸ‹y‚ÑŽû‰v‹@‰ï‚ÌŠg‘åBPL‚Ö‚Ì“ŠŽ‘‚ðŒp‘±BV‚½‚É6‚‚̗հŽŽŒ±—\’èF“Š—^ŠJŽnƒ^ƒCƒ~ƒ“ƒOB(5/10) E’ñŒgƒp[ƒgƒi[‚Ƃ̃pƒCƒvƒ‰ƒCƒ“ŠJ”­‚ÌŒp‘±“I‚Èi’»F ƒAƒ‹ƒcƒnƒCƒ}[Œ^”F’mÇŠ³ŽÒ‚ð‘ÎÛ‚Æ‚µ‚½M1 ‹y‚Ñ M4 Žó—e‘Ìì“®–ò‚Ì—Õ°ŽŽŒ±‚ɑ΂·‚éAllerganŽÐ‚©‚ç‚̒ljÁ“ŠŽ‘B E‹­—͂ŶŽY«‚Ì‚‚¢Ž©ŽÐŒ¤‹†ŠJ”­ƒvƒ‰ƒbƒgƒtƒH[ƒ€F 2018”N‰ºŠú(Q3 CY18)‚É“ú–{‚ÅDLB‚ð‘ÎÛ‚Æ‚µ‚½M1 Žó—e‘Ìì“®–ò‚Ì‘æ2‘Š PoCŽŽŒ±‚ðŠJŽn—\’èB



869:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:05:23.51 1WBY8Zjw0.net
¦SOSEI Presentation: "Sosei Group Corporation, UBS Global Healthcare Conference": Global operations and aspirations - aiming to build Japanfs first global biotech champion: Drive Global Growth Strategy. (5/21Presented, 5/22up)
EM1 Program for Alzheimerfs disease, A novel approach for symptomatic treatment of AD: Selective muscarinic M1 receptor agonism offers a potential first-in-class therapy for AD patients.
EHTL0018318 is a potential first-in-class therapy for Alzheimerfs disease: Receptor subtype selectivity is crucial. HTL0018318 has a differentiated mechanism of action with the potential to optimise symptomatic benefits in AD patients.
EHTL0018318 for DLB in Japan, Summary of Clinical Program: Clinical progress to date encouraging. Advancing preparation to commence Phase 2 PoC study in DLB in Japan in Q3 CY18.
¦Heptares: Download Corporate Presentation: "2018.06.08 Corporate Presentation (Sosei Group Corporation Corporate Presentation June 2018)". (6/8up)
¦ClinicalTrial(NCT03316898): Phase 1b, FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil}Memantine) for the Treatment of Participants with Mild to Moderate AD. Change Start: 5/20¨"2018/7/30", Add: 3 Research Sites(United States, California). (6/14update)
¦SOSEIŠ”Žå‘‰ïŽ–‹Æ•ñF¢ŠEƒgƒbƒvƒŒƒxƒ‹Šé‹Æ‚Æ‚Ì•¡”‚Ì‹¤“¯ŠJ”­ƒvƒƒOƒ‰ƒ€‚ð•Û—LF’ñŒgGPCRƒpƒCƒvƒ‰ƒCƒ“(“`““I“±oŒ^ƒ‚ƒfƒ‹/‹¤“¯Œ¤‹†ƒvƒƒWƒFƒNƒg)FƒAƒ‹ƒcƒnƒCƒ}[•a (M1, M4, M1/M4)F”F’mÇŽ¡—Âð’Ê‚¶‚½‚æ‚è—Ç‚¢–¢—ˆ‚ðŽÀŒ» (’ñŒgæFAllergan)B(6/22)
¦ClinicalTrials(NCT03456349: HTL0018318-202): Phase 1b, Multi-center Study to Determine the Safety and Tolerability of HTL0018318 in Subjects With Alzheimer's Disease Receiving Standard-of-care. Actual Study Completion: "2018/7/16". (7/20update, "Completed")
«

870:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:06:30.97 1WBY8Zjw0.net
¦ClinicalTrials(NCT03316898): Phase 1b, FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil}Memantine) for the Treatment of Participants with Mild to Moderate AD: "Change, Study Status & LocationsResearch Sites) Status". (8/16update, "Recruiting")
Study Status:
EOverall Status: Not yet Recruiting¨ "Recruiting"
EStudy Start: July 2018¨"2018/9/30"
EPrimary Completion: 2018/11/4 [Anticipated]
EStudy Completion: 2018/11/4 [Anticipated]
Locations (Research Sites): United States, California:
EATP Clinical Research (Costa Mesa, California): Not yet Recruiting¨ "Recruiting"
EIrvine Center for Clinical Research(Irvine, California): Not yet Recruiting¨ "Recruiting"
ESynergy Research Centers(Lemon Grove, California): Not yet Recruiting¨ "Recruiting"
ECollaborative Neuroscience(Long Beach, California): Not yet Recruiting
EAlliance Research(Long Beach, California): Not yet Recruiting¨ "Recruiting"
ETibor Rubin VA Medical Center(Long Beach, California): Not yet Recruiting¨ "Withdrawn"
ESyrentis Clinical Research(Santa Ana, California): Not yet Recruiting¨ "Recruiting"

871:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:24:00.53 XYmUYACPp.net
ƒs[ƒ^[‹Éˆ«

872:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:41:39.61 lhNunAIW0.net
ŒÜ–¡‚³‚ñ‚±‚ꂾ‚¯‰º‚ª‚Á‚Ä‚é‚Ì‚É‚æ‚­10‰­‰~‚à’ljÁ“ŠŽ‘o—ˆ‚é‚æ‚ËB
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873:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 06:56:24.01 MqKQaE19a.net
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874:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 07:38:34.45 Qae5GbFFM.net
ŒÜ–¡‚³‚ñƒK[Aƒs[ƒ^[ƒK[
“¯‚¶˜b‚ÌŒJ‚è•Ô‚µ

875:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 07:41:08.84 zq/dEC34x
ŒÜ–¡Ž‚Íu‰ïŽÐ‚ÌŠ”‰¿‚ªA‰ïŽÐ‚̉¿’l‚æ‚è’á‚¢v‚ÆŒ©‚Ä‚¢‚ÄA
‚»‚ê‚Å”ƒ‚


876:Á‚½‚킯‚¾BŽ©•ª‚ÍA‚»‚Ì‹t‚¾‚Æ”»’f‚µA”ƒ‚í‚È‚¢B(‰B•Á‚ª‘½‚¢‚½‚ßB)Šî–{“I‚ÉA”ƒ‚í‚È‚¢”»’f‚ÍAuŠÔˆá‚¢‚¾‚Á‚½‚Æ‚µ‚Ä‚àA‘¹‚Í‚µ‚È‚¢v‚©‚çA‚»‚ê‚à‚Ü‚½—Ç‚µB



877:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 07:42:58.94 cr0R1n9XM.net
•n–R‚¾‚©‚ç‚Ë
Š¬”E‚µ‚½‚Á‚Ä‚â

878:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:07:43.86 lhNunAIW0.net
‹C”zŽã‚¢‚Ë
‚m‚x–\“«‚Ì‚±‚ñ‚È“ú‚Å‚à‰º‚ª‚é‚ÌH

879:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:26:17.73 Qae5GbFFM.net
‚Ü‚¾‚±‚±‚ÌŠñ‚è•t‚«‘O‹C”z‚ª‚ ‚Ä‚É‚È‚ç‚ñ‚ÌŠw‚ñ‚Å‚È‚¢‚Ì‚©w
‚±‚̃XƒŒ”F’mÇ‚¾‚炯‚â‚Èw

880:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:30:44.59 +eNtna59M.net
‚Ü‚³‚©‚±‚±‚܂ʼnº‚ª‚é‚Æ‚Í‚È
‰º‚ª‚葱‚¯‚銔‚à‘¶Ý‚·‚é‚ñ‚â‚È

881:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:31:22.41 yWqau7K70.net
‚»[‚¹‚¢‚³‚ñ‚Ì‚¨–òˆù‚ñ‚¾•û‚ª@‚¢‚¢‚ËI

882:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:41:09.42 Wa0SPc970.net
ŠwK”\—Í‚ª‚ ‚é‚â‚‚Ȃ炱‚ñ‚ÈŠ””ƒ‚í‚ñ‚¾‚ë

883:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:43:25.45 Us48MbYva.net
‹C”z‘å–\—Žw

884:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:49:19.36 yWqau7K70.net
‚`ƒUƒC@‚È‚ñ‚©‚«‚Ä‚ñ‚Ë

885:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:50:57.74 EvB+hmrW0.net
ð“ú‚ª¢‹I‚Ì‘å’ꂾ‚Á‚½‚©‚È

886:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:54:29.80 Wa0SPc970.net
¡”N536‰ñ–Ú‚Ì’ê‘Å‚¿—ˆ‚Ä‚µ‚Ü‚Á‚½‚©

887:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:55:39.89 Us48MbYva.net
>>840
ƒ‰ƒCƒoƒ‹¬Œ÷‚ÅA‚Ü‚·‚Ü‚·‚»[‚¹‚¢•s—v‚É

888:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 08:56:15.15 yWqau7K70.net
‹C”z’l‚ª@‚™WìB

889:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 09:01:55.67 EvB+hmrW0.net
‚»[‚¹‚¢–¼•¨ ”„‚è“Ø‚ÌÄ‚«s‚­‚µ

890:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 09:05:00.43 /dz3w4YX8
ƒoƒJƒ‹ƒT–ٔ錠sŽgBÎB

891:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 09:07:33.13 3LnyzE0j0.net
‚Ç‚¤‚µ‚½H¡“ú‚ÍH
‘ä•—‚Å‚à—ˆ‚é‚©‚ç‚â‚ß‚Ä‚­‚ê‚—

892:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 09:13:27.41 Us48MbYva.net
>>845
‚±‚Ì‚ ‚Æ‚Ü‚³‚©‚̃}ƒC“]ˆÀ’lˆø‚¯A—¼“Ø‚±‚낵

893:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 09:31:45.92 zjsMuW+30.net
ƒ~ƒi‚É‹à@‘Ž‘‚µ‚È‚¢‚Æã‚°‚邵‚©‚È‚¢
ˆ«“¿@ƒs[ƒ^[‚¨‘O‚¾‚æ@‘R‚é‚ׂ«‚Æ‚±‚ë‚É’²‚ׂĂà‚炤‚©‚ç‚È

894:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 10:07:37.60 /dz3w4YX8
”„‚è“Ø

@‹z‚Á‚Ä`@‚Í‚¢‚Ä`@‚·‚Á‚Ä`@‚Í‚¢‚Ä`@Ž~‚ß‚Ä`BÎB

895:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 10:26:29.70 228i8egE0.net
“ú–{Œê‚Å‚¨k

896:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 11:25:05.33 h2ITVKiQd.net
ƒXƒŒ‚ªŒ³‹C‚È‚¢Žž‚Íオ‚Á‚Ă鎞

897:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 11:30:46.22 /dz3w4YX8
‰°•aƒoƒJƒ‹ƒTBÎB

898:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 11:42:31.45 zdFE+wDO0.net
‚²‚Ý‚³‚ñ‘å–ׂ¯‚©‚æ‚­‚»

899:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:08:29.27 yWqau7K70.net
‚à‚µ‚©‚µ‚½‚ç¡“ú‚Ì‚»[‚¹‚¢‚³‚ñA’¶Žq‚±‚«™‚¾‚ÈB

900:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:10:03.19 n9E//HPVp.net
ŒÜ–¡‚³‚ñ‚Ì”ƒ‚¢‘‚µ‚Ɉê•[

901:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:19:41.87 2/qgqLca.net
ƒoƒJƒ‹ƒT‚Ç‚¤‚µ‚½HiÎj

902:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:23:52.37 /dz3w4YX8
ƒoƒJƒ‹ƒT—l‚²—ÕI‚Å‚·B‚ ‚ê‚Ù‚Ç‹ó”„‚è‚Í‚â‚ß‚Ä‚¨‚¯‚ÆŒ¾‚Á‚½‚Ì‚É

903:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:20:45.38 H+j5tjaVd.net
ƒ}ƒC“]‚µ‚½‚炽‚­‚³‚ñ‚Å‚Ä‚«‚»‚¤w

904:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:33:12.05 yWqau7K70.net
‚Ç[[[‚ñB

905:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:50:15.11 Qae5GbFFM.net
‚΂¢[[‚ñw

906:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 12:53:38.94 yWqau7K70.net
¡“ú‚Ì‚»[‚¹‚¢‚³‚ñA‚µ‚Ô‚Ä‚¦‚¦[B

907:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 13:02:07.05 skVI6TmM0.net
ƒ\ƒŒƒCƒWƒAˆê“ú‚Å30“ã‚°‚é‚Æ‚©‚³
–{—ˆ‚Å‚ ‚ê‚΂»[‚¹‚¢‚ª‚»‚̈Êオ‚Á‚Ä‚à‚¦‚¦‚ñ‚₼I
‚±‚Ì•³Š”‚您

908:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 13:11:40.98 skVI6TmM0.net
¡‚ÌŠ”‰¿1260‰~‚©‚ç30“オ‚Á‚Ä‚à1638‰~‚Æ‚©ƒ}ƒW‚ŃMƒƒƒO‚©‚æ
Žè‚ÁŽæ‚è‘‚­2000‰~ˆÊ‚ÅTOB‚µ‚Ä‚à‚ç‚¢‚Ä‚¦‚í

909:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 13:23:29.97 /dz3w4YX8
’N‚ª”ƒ’lˆÈ‰º‚ÅŽ^“¯‚·‚é‚ñ‚¾HŠ””ƒ‚Á‚Ä‚©‚ço’¼‚µ‚Ä—ˆ‚¢

910:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 13:38:35.73 /dz3w4YX8
‚P‰~‚Ü‚Å‹ó”„‚Á‚½‚ç‚Q‰~‚Å”ƒŽû‚Å‚«‚é‚킯‚¶‚á‚È‚¢‚ñ‚¾‚æ

911:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 13:40:57.85 m/D+RaOGr.net
–{“ú‚Ì“VˆäŠm”F
‚ ‚Ƃ͉º‚ª‚邾‚¯

912:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:14:53.22 HUgXcuocM.net
¡“ú‚̓oƒCƒI‚Ì—Y‚Æ‚µ‚ÄŽsê‚ðŒ¡ˆø‚µ‚Ä‚¢‚é‚È

913:ƒoƒPƒc‘å²
18/08/17 14:26:05.96 ohhslYiY0.net
27000‰~‚Å”ƒ‚Á‚Ä1180‚Å”„‚Á‚Ä‚â‚Á‚½‚¼

914:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:34:46.27 pNQ7ZUo9a.net
>>869
ƒiƒCƒXƒgƒŒ[ƒh

915:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:39:58.91 yWqau7K70.net
¡“ú‚̓lƒ^‚Ìo‚½‚`ƒUƒC‚ª‰º‚ª‚Á‚ÄA
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Š”‚Á‚Ä‚¢‚¢‰ÁŒ¸‚¾‚ÈEEEB

916:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:45:10.28 1t8NqvYva.net
‚â‚Á‚Æ¡“ú‚©B’·‚©‚Á‚½‚ÈB

917:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:46:01.20 pNQ7ZUo9a.net
‚‚ê‚Ä‚«‚½II
‚Ü‚³‚©‚̃}ƒC“]‚ ‚é‚æ

918:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:46:30.54 yWqau7K70.net
•Â“X‚Ü‚Å‚ ‚Æ‚P‚S•ªB
¡“ú‚̃}ƒC“_‚Í‚à‚¤–³—‚¾IHH

919:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 14:47:06.48 pNQ7ZUo9a.net
‹ó”„‚èŠOŽ‘‚ª–{‹Co‚µ‚½‚ç1•ª‚Ń}ƒC“]

920:ŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†
18/08/17 15:02:25.34 /dz3w4YX8
ƒoƒJƒ‹ƒT@ƒoƒCƒIƒXƒŒ‚Å‚à¸_•aˆµ‚¢BÎB

368 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:36:25.33 ID:wJRoj7tZa.net[5/7]
>>367
‚»[‚¹‚¢‚àƒTƒ“ƒo‚àŽ¸”s‚·‚é‚æ
‹ó”„‚èŠOŽ‘‚ª¬Œ÷‚³‚¹‚é‚킯‚È‚¢‚â‚ë

370 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:41:50.68 ID:gtvG2X9U0.net[1/2]
>>369
‚»[‚¹‚¢‚͉½‚©Š”‰¿‚ª“®‚«‚»‚¤‚ÈÞ—¿‚ªo‚»‚¤‚¾‚Á‚½‚Á‚¯H
371 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:44:57.27 ID:wJRoj7tZa.net[6/7]
>>370
‰½‚à‚È‚¢‚æ
‚ ‚é‚Æ‚µ‚½‚犔‰¿‚ª‰º‚ª‚éÞ—¿‚¾‚¯
372 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:49:12.34 ID:XkV2JVCjk[3/4]
‚»[‚¹‚¢¡ŒŽ‚̃Iƒ‰ƒr‚à“–‚Ä‚½‚çƒtƒF[ƒY‡U‚Ü‚Å‚¢‚Á‚½‰»‡•¨‚Í‚S˜A‘±ãŽs‚É‚È‚é‚©H
“c‘º‰ï’·‚Ì–Ú—˜‚«‚ªŒ…ˆá‚¢‚È‚ñ‚¶‚á‚ËH
373 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:48:29.32 ID:eUGorfOEp.net[2/2]
>>370
ƒŒƒr[¬‘̃tƒF[ƒY‚QŠJŽn
‘¼‚Ì‚Q‚‚æ‚è‚ÍŽã‚¢‚©‚È‚ 
374 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:49:06.42 ID:wJRoj7tZa.net[7/7]
>>373
‚»‚ñ‚È‚ÌD‚èž‚ÝÏ‚Ý
375 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:50:08.11 ID:E63caVas0.net[1/2]
‹ó”„‚è‹@ŠÖ‚ªŽ¡Œ±Œ‹‰Ê‚ɉe‹¿‚·‚é‚Í‚¸‚ª‚È‚¢
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376 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:52:08.33 ID:YPKd99+U0.net[3/4]
>>375
‚¿‚å‚Á‚Ɖ½Œ¾‚Á‚Ä‚ñ‚Ì‚©‚í‚©‚’

379 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:53:49.71 ID:4c1c+E2ra.net[2/2]
ˆêÌ‘O‚Í“Á‹–‚Æ‚©‚Å‚àオ‚Á‚Ä‚½‚ÈB
オ‚éÞ—¿‚Á‚Ä’è‹`‚ª“‚¢‚æB

381 FŽRŽt‚³‚ñ—ƒgƒŒ[ƒh’†F2018/08/16(–Ø) 12:57:05.25 ID:E63caVas0.net[2/2]
>>376
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